Back to Search
Start Over
Quantitative assessment and determinants of the papillary microvasculature in healthy subjects
- Source :
- BMC Ophthalmology, Vol 21, Iss 1, Pp 1-8 (2021), BMC Ophthalmology
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background It is critical to monitor the optic disc’s vessel density using Optical coherence tomography angiography (OCTA) and evaluate its determinants. In the current study, we investigate the superficial vessel density (VD) of the papillary microvasculature and its determinants in healthy subjects of Southern China. Methods This was a prospective, cross-sectional study. Superficial VD in healthy individuals’ optic disc region was measured by OCTA. The factors associated with ocular and systemic parameters were analyzed using a generalized estimation equation (GEE) model. Results A total of 510 eyes of 260 healthy subjects were analyzed in the study. The total VD in the optic disc area was 17.21 ± 2.15 mm− 1 (95% CI, 17.02–17.40 mm− 1). The VD in the inner ring and the outer ring of the optic disc were significantly higher compared with the central ring, while the VD of the superior quadrant and inferior quadrant was significantly higher compared with the temporal and nasal quadrant. After adjusting for the ocular factors and systemic factors, AL (β = − 0.4917, P = 0.0003), disc area (β = − 0.3748, P = 0.0143), CMT (β = − 0.0183, P = 0.0003) and SSI (β = 1.0588, P Conclusion The mean total VD in the optic disc area was 17.21 ± 2.15 mm− 1 in healthy subjects, and the superior and inferior VD was significantly higher than the temporal and nasal VD. AL, disc area, CMT, and SSI may affect the total VD in the optic disc area and should be considered in clinical practice.
- Subjects :
- China
medicine.medical_specialty
genetic structures
Quadrant (abdomen)
Axial length
lcsh:Ophthalmology
Ophthalmology
Quantitative assessment
medicine
Humans
Prospective Studies
Healthy subjects
Fluorescein Angiography
Optic disc
Superficial vessel density
business.industry
Retinal Vessels
General Medicine
Optical coherence tomography angiography
Healthy Volunteers
eye diseases
Clinical Practice
Cross-Sectional Studies
medicine.anatomical_structure
Southern china
lcsh:RE1-994
Healthy individuals
Microvessels
sense organs
business
Tomography, Optical Coherence
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712415
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Ophthalmology
- Accession number :
- edsair.doi.dedup.....22a8ae3d9ebb6f4f132f534c25feacbf