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Differences in oncological outcomes and inflammatory biomarkers between right‐sided and left‐sided stage I‐III colorectal adenocarcinoma
- Source :
- Journal of Clinical Laboratory Analysis
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Background The aim of this study was to investigate the differences in oncological outcome and inflammatory biomarkers between right‐sided colon cancer (RCC) and left‐sided colorectal cancer (LCRC). Methods We retrospectively analyzed 339 patients with stage I‐III colorectal cancer, including 125 RCC patients and 214 LCRC patients, who underwent radical resection from January 2012 to January 2014. Comparison of neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR) between RCC and LCRC was evaluated using the Mann‐Whitney U test. Overall survival (OS) and disease‐free survival (DFS) were analyzed using Kaplan‐Meier analysis and compared using the log‐rank test. Univariate and multivariate Cox regression analyses were used to identify the prognostic value of inflammatory markers. Results Patients with RCC had higher NLR (P = .002) and PLR (P
- Subjects :
- 0301 basic medicine
Oncology
Male
Multivariate analysis
Colorectal cancer
Clinical Biochemistry
Kaplan-Meier Estimate
urologic and male genital diseases
0302 clinical medicine
platelet‐to‐lymphocyte ratio
Immunology and Allergy
Stage (cooking)
Research Articles
Hematology
Middle Aged
neutrophil‐to‐lymphocyte ratio
Prognosis
Inflammatory biomarkers
Medical Laboratory Technology
Treatment Outcome
030220 oncology & carcinogenesis
Female
Colorectal Neoplasms
Research Article
Microbiology (medical)
medicine.medical_specialty
overall survival
Adenocarcinoma
lymphocyte‐to‐monocyte ratio
Disease-Free Survival
03 medical and health sciences
Internal medicine
Overall survival
medicine
Biomarkers, Tumor
Humans
Neutrophil to lymphocyte ratio
right/left‐sided colorectal adenocarcinoma
inflammatory biomarkers
Neoplasm Staging
Inflammation
oncological outcomes
Proportional hazards model
business.industry
Biochemistry (medical)
Public Health, Environmental and Occupational Health
medicine.disease
030104 developmental biology
Multivariate Analysis
Mann–Whitney U test
business
Subjects
Details
- Language :
- English
- ISSN :
- 10982825 and 08878013
- Volume :
- 34
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Laboratory Analysis
- Accession number :
- edsair.doi.dedup.....22bee3ea70ab4d542329035ac5da2986