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Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center
- Source :
- Canadian Journal of Physiology and Pharmacology. 100:5-11
- Publication Year :
- 2022
- Publisher :
- Canadian Science Publishing, 2022.
-
Abstract
- The optimal cutoff point for evaluating the prognosis of localized renal cell carcinoma (LRCC) remains unclear. This study aimed to verify the efficacy of tumor diameter in the 2010 American Joint Committee on Cancer (AJCC) TNM staging system and contribute to the modification of TNM staging on the prognosis of this disease. A total of 3748 patients with LRCC were enrolled and grouped according to the 2010 AJCC TNM staging system. COX analysis was used to stratify the prognosis. The optimal cutoff point of the tumor diameter in the T1 and T2 prognosis was explored. There were 3330 (88.9%) patients in stage T1 and 418 (11.1%) in stage T2. The cancer-specific mortality rate was 2.7% (100/3748). The mean follow-up was 49.8 months. A tumor diameter of 7 cm can determine the prognosis of patients at stages T1 and T2; however, 4.5 cm and 11 cm as the cutoff points for T1 and T2 sub-classification of patients with LRCC might show better recognition ability than 4 cm and 10 cm, respectively. The 2010 AJCC TNM stage can predict the prognosis of LRCC in stages T1 and T2. In addition, a tumor diameter of 4.5 cm and 11 cm might be the optimal cutoff points for the sub-classification of stages T1 and T2.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Physiology
TNM staging system
Single Center
Young Adult
Renal cell carcinoma
Physiology (medical)
Humans
Medicine
Cutoff
Stage (cooking)
Child
Carcinoma, Renal Cell
Aged
Neoplasm Staging
Proportional Hazards Models
Aged, 80 and over
Pharmacology
Tumor size
business.industry
Infant
Cancer
General Medicine
Middle Aged
Prognosis
medicine.disease
Kidney Neoplasms
Child, Preschool
TNM Staging
Female
Radiology
business
Subjects
Details
- ISSN :
- 12057541 and 00084212
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Accession number :
- edsair.doi.dedup.....22e238478f46dfacdaa9976a88a66e72