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Assessment of arterial stiffness for clinical and epidemiological studies: methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry
- Source :
- Nephrology Dialysis Transplantation. 29:232-239
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Epidemiological studies have highlighted the role of arterial stiffness as a risk factor for development of cardiovascular (CV) diseases. Moreover, aortic stiffness has been shown to be a significant predictive factor of all-cause and CV mortality in different populations including patients with end-stage renal disease. Pulse-wave velocity (PWV) is the most widely used technique to assess arterial stiffness. Although PWV can be measured on any artery or between any arterial sites, only carotid-to-femoral PWV, representing stiffness of the aorta and iliofemoral axes, has been shown to have predictive value for morbidity and mortality. The several available commercial devices differ according to the type of signal (pressure, distension, flow) or by recording both sites simultaneously or using ECG synchronization. It is also possible to directly measure arterial diameter changes during the cardiac cycle and link them to local pulse-pressure changes, which provides the pressure-diameter relationship and stress-strain relationship if arterial wall thickness is also measured. These techniques are based on high-precision vascular echo tracking or magnetic resonance imaging and applanation tonometry. This paper summarizes the basic principles of arterial haemodynamics and various methodologies to assess stiffness and the latest consensus recommendations for clinical applications.
- Subjects :
- medicine.medical_specialty
aortic pressure, arterial stiffness, elastic modulus, pulse-wave velocity
Hemodynamics
Blood Pressure
Risk Assessment
Vascular Stiffness
Risk Factors
medicine.artery
Internal medicine
medicine
Humans
Registries
Pulse wave velocity
Transplantation
Aorta
business.industry
Reproducibility of Results
MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Arteries
medicine.disease
Europe
Survival Rate
Epidemiologic Studies
medicine.anatomical_structure
Cardiovascular Diseases
Nephrology
Arterial stiffness
Aortic pressure
Cardiology
Kidney Failure, Chronic
Aortic stiffness
business
Artery
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....22e7e9ccd6cbde77b923ab6598cfd882