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Association between CSF Aβ42 and amyloid negativity in patients with different stage mild cognitive impairment
Association between CSF Aβ42 and amyloid negativity in patients with different stage mild cognitive impairment
- Source :
- Neuroscience letters. 754
- Publication Year :
- 2020
-
Abstract
- Whether the cerebrospinal fluid (CSF) biomarkers of amyloid-positive and amyloid-negative patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD) are significantly different is still unknown. The purpose of this study is to compare the differences in CSF total tau, P-tau and Aβ42 in patients with amyloid-positive positron emission tomography (PET) and amyloid-negative PET, and to explore related risk factors in cognitive normal (CN), early MCI (EMCI), late MCI (LMCI) and AD. 558 participants (140 CN; 233 EMCI; 125 LMCI; 60 AD) were recruited in this study from the AD Neuroimaging Initiative (ADNI) database. The associations between CSF biomarkers were assessed by partial correlation analysis. The relations between significant variables were determined by multinomial logistic regression. Compared with amyloid-positive PET patients, patients with amyloid-negative PET had higher CSF Aβ42 and lower P-tau in the whole samples. The concentration of Aβ42 in the positive amyloid PET was significantly different in different groups, but not the negative amyloid PET (CN vs. LMCI; CN vs. AD; EMCI vs. AD, all P0.05). When amyloid PET was positive, a weak correlation was found between the levels of Aβ42 and P-tau only in CN group. However, a moderate degree of correlation between Aβ42 and P-tau was found in EMCI and LMCI when amyloid PET was negative. After covariates adjustment, CSF Aβ42 was significantly associated with EMCI [adjusted odds ratio (OR) = 0.99, 95 % confidence interval (CI) = 0.99-1.00, P = 0.02) and LMCI (adjusted OR = 0.99, 95 % CI = 0.99-1.00, P = 0.007)] in patients with negative amyloid PET, not in patients with positive amyloid PET. Our findings highlight that Aβ42 had strong correlations with other biomarkers and might help reduce risk of EMCI or LMCI in patients with amyloid negativity.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Amyloid
tau Proteins
Severity of Illness Index
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Neuroimaging
Alzheimer Disease
Internal medicine
mental disorders
medicine
Humans
In patient
Cognitive Dysfunction
Stage (cooking)
Cognitive impairment
Aged
Aged, 80 and over
Amyloid beta-Peptides
medicine.diagnostic_test
business.industry
General Neuroscience
Brain
Negativity effect
Mental Status and Dementia Tests
Peptide Fragments
030104 developmental biology
Positron emission tomography
Positron-Emission Tomography
Female
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 754
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....22efa5d0168a58c38afcd6ee7add385f