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Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, LLC, 2021.
-
Abstract
- Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS). Previous work suggests that CBF differs between men and women, and declines with age and certain pathologies, but a highly controlled systematic study across a wide age range, and incorporating white matter (WM) regions, has not been undertaken. Here, we investigate age- and sex-related differences in CBF in gray matter (GM) and WM regions in a cohort (N = 80) of cognitively unimpaired individuals over a wide age range. In agreement with literature, we find that GM regions exhibited lower CBF with age. In contrast, WM regions exhibited higher CBF with age in various cerebral regions. We attribute this new finding to increased oligodendrocyte metabolism to maintain myelin homeostasis in the setting of increased myelin turnover with age. Further, consistent with prior studies, we found that CBF was higher in women than in men in all brain structures investigated. Our work provides new insights into the effects of age and sex on CBF. In addition, our results provide reference CBF values for the standard ASL protocol recommended by the ISMRM Perfusion Study Group and the European ASL in Dementia consortium. Thus, these results provide a foundation for further investigations of CNS perfusion in a variety of settings, including aging, cerebrovascular diseases, and dementias.
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
cerebral blood flow
Central nervous system
White matter
Myelin
Sex Factors
Internal medicine
medicine
Humans
Dementia
Gray Matter
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Age Factors
Magnetic resonance imaging
Cell Biology
Middle Aged
medicine.disease
arterial spin labeling
Magnetic Resonance Imaging
White Matter
Healthy Volunteers
Oligodendrocyte
medicine.anatomical_structure
Cerebral blood flow
Cerebrovascular Circulation
Cardiology
Female
business
Perfusion
Research Paper
MRI
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....22ff9048b4d40cb454f3c83ff9b5b382