Back to Search
Start Over
The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
- Source :
- Journal of Neuroimmunology, Journal of Neuroimmunology, Elsevier, 2010, 224 (1-2), pp.93-100. ⟨10.1016/j.jneuroim.2010.05.010⟩
- Publication Year :
- 2010
-
Abstract
- International audience; Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as well as during chronic affections like multiple sclerosis or Alzheimer's disease, inflammation occurs in order to "clean up" the lesion and to limit its area. Nevertheless, prolonged and sustained inflammation may have cytotoxic effects, aggravating the incidence and the severity of the disease. Among molecules produced during inflammation associated to neuronal death, monocyte chemoattractant proteins (MCPs) seem to be particularly important. This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.
- Subjects :
- CCR2
Chemokine
MESH: Chemotaxis, Leukocyte
0302 clinical medicine
Neuroinflammation
MESH: Receptors, CCR2
Immunology and Allergy
MESH: Animals
Chemokine CCL2
0303 health sciences
biology
Brain
Alzheimer's disease
3. Good health
Stroke
Chemotaxis, Leukocyte
Neurology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
medicine.symptom
Chemokines
CCL2
Monocyte Chemoattractant Proteins
Multiple Sclerosis
Receptors, CCR2
Immunology
Inflammation
MESH: Strok
Lesion
03 medical and health sciences
MESH: Brain
Immune system
Alzheimer Disease
medicine
Animals
Humans
MESH: Chemokine CCL2
030304 developmental biology
MESH: Humans
business.industry
Multiple sclerosis
MESH: Multiple Sclerosis
medicine.disease
biology.protein
Neurology (clinical)
business
030217 neurology & neurosurgery
MESH: Alzheimer Disease
Subjects
Details
- ISSN :
- 18728421 and 01655728
- Volume :
- 224
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....2303ff73c904b9a0e9dfb18c66b6be6c