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The relationship of MicroRNA-21 and plaque stability in acute coronary syndrome
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Acute coronary syndrome (ACS) leads to clinical symptoms such as chest pain, dyspnea, and arrhythmia. The occurrence of ACS is mainly related to the vulnerable plaques in the coronary arteries. MicroRNA-21 (miR-21) is widely expressed in cardiovascular disease and considered as a marker of myocardial infarction, but its role in vulnerable atherosclerotic plaque of ACS is poorly studied. The cases of ACS and control group were selected in 2 years. Our results revealed that miR-21 was highly positively correlated with the maximum lipid core area, the number of diseased vessels, the number of macrophages, the number of vulnerable plaques, and negatively correlated with the thickness of fiber caps. In the high expression group, the number of coronary artery lesions, the number of vulnerable plaques, the core area of lipid pools and the number of macrophages were significantly higher than those in the low expression group and the middle expression group. But the high expression group of the thickness of the fiber cap was significantly lower than that of the low expression group and the medium expression group. These studies show that miR-21 is an important factor leading to vulnerable plaque instability in ACS, and it can be a predictor of acute adverse events in coronary heart disease.
- Subjects :
- Male
medicine.medical_specialty
Acute coronary syndrome
Observational Study
Disease
medicine.disease_cause
Chest pain
acute coronary syndrome
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
030212 general & internal medicine
Myocardial infarction
Adverse effect
optical coherence tomography
business.industry
General Medicine
Middle Aged
medicine.disease
Vulnerable plaque
Plaque, Atherosclerotic
Coronary arteries
MicroRNAs
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cardiology
Female
medicine.symptom
vulnerable plaques
business
Research Article
microRNA-21
Artery
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....23398f60523f7eca1219b531e827cc4a