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Immunohistochemical evaluation of vasopressin expresion in breast fibrocystic disease and ductal carcinoma In situ (DCIS)
- Source :
- Endocrine Pathology. 14:257-262
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- We previously found that expression of the vasopressin gene is a common feature of human breast cancer. In the present study we first examined 21 different cases of benign fibrocystic breast disease for vasopressin expression using immunohistochemistry and antibodies directed against vasopressin (anti-VP) and against vasopressin-associated glycopeptide (anti-VAG). All cases examined were negative for vasopressin gene expression using these antibodies. Alternatively, we examined 16 cases of breast ductal carcinoma in situ (DCIS) using the second of these antibodies (anti-VAG), and all of these cases were positive for vasopressin gene expression. Our results suggest that products of vasopressin gene expression are not markers of cellular proliferation in the breast, and might rather represent an early part of the carcinogenic process in this tissue.
- Subjects :
- Pathology
medicine.medical_specialty
Vasopressin
Fibrocystic Breast Disease
Vasopressins
Biopsy
Endocrinology, Diabetes and Metabolism
Breast Neoplasms
Pathology and Forensic Medicine
Endocrinology
Ductal carcinoma in situ (DCIS)
Gene expression
medicine
Humans
skin and connective tissue diseases
Gene
Retrospective Studies
biology
business.industry
Cancer
General Medicine
medicine.disease
Immunohistochemistry
Carcinoma, Ductal
Gene Expression Regulation, Neoplastic
biology.protein
Female
Antibody
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15590097 and 10463976
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Endocrine Pathology
- Accession number :
- edsair.doi.dedup.....235f46d670f4d65ade7d7d0d53c7cb38
- Full Text :
- https://doi.org/10.1007/s12022-003-0018-y