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Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
- Source :
- Journal of Clinical Medicine, Vol 10, Iss 3436, p 3436 (2021), Journal of Clinical Medicine, Volume 10, Issue 15
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intelligence technology. Of 302 patients who survived for &gt<br />36 months after surgery were analyzed. Multivariate logistic regression analysis for factors affecting body composition changes and repeated-measures analysis of variance to observe differences in the course of change according to each factor were performed. In logistic analysis, preoperative sarcopenia and recurrence were the main factors influencing body composition changes at 1 and 3 years after surgery, respectively. In changes of longitudinal body composition, the decrease in body composition was the greatest at 3–6 months postoperatively, and the preoperative status did not recover even 3 years after surgery. Especially, males showed a greater reduction in skeletal muscle (SKM) after surgery than females (p &lt<br />0.01). In addition, SKM (p &lt<br />0.001) and subcutaneous adipose tissue (p &lt<br />0.05) mass rapidly decreased in case of recurrence. In conclusion, long-term survivors of pancreatic cancer did not recover their preoperative body composition status, and preoperative sarcopenia and recurrence influenced body composition changes.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
recurrence
Logistic regression
Gastroenterology
Article
surgery
sarcopenia
03 medical and health sciences
0302 clinical medicine
Internal medicine
Pancreatic cancer
Medicine
skin and connective tissue diseases
body composition
business.industry
pancreatic neoplasms
General Medicine
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Sarcopenia
Logistic analysis
Analysis of variance
Subcutaneous adipose tissue
sense organs
Abdominal computed tomography
business
Pancreatic head cancer
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 3436
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....236135b62acf2ea070b3beb9eab56506