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Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes

Authors :
Yousun Ko
Jae Hoon Lee
Ki Byung Song
Hyun-Ho Kong
Dae Wook Hwang
Kyung Won Kim
Song Cheol Kim
Won Gu Kim
Source :
Journal of Clinical Medicine, Vol 10, Iss 3436, p 3436 (2021), Journal of Clinical Medicine, Volume 10, Issue 15
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intelligence technology. Of 302 patients who survived for &gt<br />36 months after surgery were analyzed. Multivariate logistic regression analysis for factors affecting body composition changes and repeated-measures analysis of variance to observe differences in the course of change according to each factor were performed. In logistic analysis, preoperative sarcopenia and recurrence were the main factors influencing body composition changes at 1 and 3 years after surgery, respectively. In changes of longitudinal body composition, the decrease in body composition was the greatest at 3–6 months postoperatively, and the preoperative status did not recover even 3 years after surgery. Especially, males showed a greater reduction in skeletal muscle (SKM) after surgery than females (p &lt<br />0.01). In addition, SKM (p &lt<br />0.001) and subcutaneous adipose tissue (p &lt<br />0.05) mass rapidly decreased in case of recurrence. In conclusion, long-term survivors of pancreatic cancer did not recover their preoperative body composition status, and preoperative sarcopenia and recurrence influenced body composition changes.

Details

Language :
English
ISSN :
20770383
Volume :
10
Issue :
3436
Database :
OpenAIRE
Journal :
Journal of Clinical Medicine
Accession number :
edsair.doi.dedup.....236135b62acf2ea070b3beb9eab56506