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Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages
- Source :
- Aging (Albany NY)
- Publication Year :
- 2019
-
Abstract
- Reactive oxygen species (ROS) modulator 1 (Romo1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. Although the physiological functions of Romo1 have been studied for the past few years, the role of Romo1 in cancer remained unclear. In this study, we found that the high expression of Romo1 is associated with the poor prognosis of glioblastoma patients. Further study revealed that Romo1 is highly expressed in macrophages, indicating that the overexpression of Romo1 may participate in the function of macrophages and contribute to the progression of glioblastoma. Through the glioblastoma mouse model, we found that the overexpression of Romo1 in bone marrow cells significantly inhibited the immune response within tumor microenvironment, and that the overexpression of Romo1 resulted in the M2 polarization of bone marrow derived macrophages (BMDMs) through mTORC1 signaling pathway. In addition, the inhibition of Romo1 combining with anti-PD-1 immunotherapy significantly improved the survival outcome of glioblastoma in mouse model. Collectively, our study highlights the important role of Romo1 in immune response especially the function of macrophages, and implicates it as a potential target of immunotherapy for glioblastoma.
- Subjects :
- Mitochondrial ROS
Aging
medicine.medical_treatment
Biology
Romo1
immune response
Mitochondrial Proteins
Mice
Immune system
Cell Line, Tumor
medicine
Animals
Humans
chemistry.chemical_classification
Reactive oxygen species
Tumor microenvironment
Macrophages
Immunity
glioblastoma
Cancer
Membrane Proteins
Cell Biology
Immunotherapy
Macrophage Activation
medicine.disease
medicine.anatomical_structure
chemistry
Mitochondrial Membrane Protein
Cancer research
Bone marrow
Disease Susceptibility
immunotherapy
Energy Metabolism
Reactive Oxygen Species
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....23783a0846c36f5a5085168d2d3eea5d