Back to Search
Start Over
Curculigo recurvata W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model
- Source :
- Animal Models and Experimental Medicine, Animal Models and Experimental Medicine, Vol 3, Iss 2, Pp 169-181 (2020)
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Background Curculigo recurvata (C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti‐nociceptive and anti‐diarrheal effects of a C. recurvate rhizome methanol extract (Me‐RCR). Methods The analgesic effects of Me‐RCR were assessed using acetic acid‐induced writhing and the formalin‐induced flicking test. The drugs were administered intraperitoneally (IP) at doses of 200 and 400 mg/kg body weight (bw). Anti‐diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti‐nociceptive and anti‐diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best‐fit phytoconstituents. Results The Me‐RCR showed significant (P
- Subjects :
- Medicine (General)
biology
Chemistry
Curculigo recurvata
Analgesic
General Medicine
Original Articles
Pharmacology
Secondary metabolite
analgesic
biology.organism_classification
Curculigo
Rhizome
Excretion
R5-920
In vivo
isocurculigine
Toxicity
medicine
Original Article
anti‐diarrheal
curculigine
anti‐nociceptive
ADME
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 25762095 and 20965451
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Animal Models and Experimental Medicine
- Accession number :
- edsair.doi.dedup.....237932772356a04d6cd779faea28c13d