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A New Splice Variant of Glial Fibrillary Acidic Protein, GFAPε, Interacts with the Presenilin Proteins

A New Splice Variant of Glial Fibrillary Acidic Protein, GFAPε, Interacts with the Presenilin Proteins

Authors :
Bjarne Bonven
Ida Elisabeth Holm
Arne Lund Jørgensen
Anders Lade Nielsen
Poul Jørgensen
Marianne Gregers Johansen
Source :
Nielsen, A L, Holm, I E, Johansen, M, Bonven, B, Jørgensen, P & Jørgensen, A L 2002, ' A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins ', Journal of Biological Chemistry, vol. 277, no. 33, pp. 29983-91 . https://doi.org/10.1074/jbc.M112121200
Publication Year :
2002
Publisher :
Elsevier BV, 2002.

Abstract

Udgivelsesdato: 2002-Aug-16 We describe a new human isoform, GFAP epsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAP epsilon mRNA is the result of alternative splicing and a new polyadenylation signal, and thus GFAP epsilon has a new C-terminal protein sequence. This provides GFAP epsilon with the capacity for specific binding of presenilin proteins in yeast and in vitro. Our observations suggest a direct link between the presenilins and the cytoskeleton where GFAP epsilon is incorporated. Mutations in GFAP and presenilins are associated with Alexander disease and Alzheimer's disease, respectively. Accordingly, GFAP epsilon should be taken into consideration when studying neurodegenerative diseases.

Details

ISSN :
00219258
Volume :
277
Database :
OpenAIRE
Journal :
Journal of Biological Chemistry
Accession number :
edsair.doi.dedup.....2379950c15695b5d5e53ef9b6ba10768
Full Text :
https://doi.org/10.1074/jbc.m112121200