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A New Splice Variant of Glial Fibrillary Acidic Protein, GFAPε, Interacts with the Presenilin Proteins
A New Splice Variant of Glial Fibrillary Acidic Protein, GFAPε, Interacts with the Presenilin Proteins
- Source :
- Nielsen, A L, Holm, I E, Johansen, M, Bonven, B, Jørgensen, P & Jørgensen, A L 2002, ' A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins ', Journal of Biological Chemistry, vol. 277, no. 33, pp. 29983-91 . https://doi.org/10.1074/jbc.M112121200
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Udgivelsesdato: 2002-Aug-16 We describe a new human isoform, GFAP epsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAP epsilon mRNA is the result of alternative splicing and a new polyadenylation signal, and thus GFAP epsilon has a new C-terminal protein sequence. This provides GFAP epsilon with the capacity for specific binding of presenilin proteins in yeast and in vitro. Our observations suggest a direct link between the presenilins and the cytoskeleton where GFAP epsilon is incorporated. Mutations in GFAP and presenilins are associated with Alexander disease and Alzheimer's disease, respectively. Accordingly, GFAP epsilon should be taken into consideration when studying neurodegenerative diseases.
- Subjects :
- DNA, Complementary
Polyadenylation
Molecular Sequence Data
macromolecular substances
Saccharomyces cerevisiae
Plasma protein binding
Biology
Biochemistry
Presenilin
Sequence Homology, Nucleic Acid
Glial Fibrillary Acidic Protein
Presenilin-2
mental disorders
Presenilin-1
medicine
Animals
Humans
Amino Acid Sequence
Molecular Biology
Peptide sequence
Base Sequence
Sequence Homology, Amino Acid
Glial fibrillary acidic protein
Alternative splicing
Membrane Proteins
Exons
Cell Biology
medicine.disease
Alexander disease
Alternative Splicing
nervous system
Membrane protein
biology.protein
Protein Binding
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 277
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....2379950c15695b5d5e53ef9b6ba10768
- Full Text :
- https://doi.org/10.1074/jbc.m112121200