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Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome

Authors :
Funda Coskun
R. Oktay Gözü
Yesim Ozarda Ilcol
Ilker Ercan
Mehmet Karadag
Ahmet Ursavaş
Basak Burgazlioglu
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.
Ursavaş, Ahmet
Karadağ, Mehmet
İlçöz, Yasemin
Ercan, İlker
Burgazoğlu, Başak
Coşkun, Funda
Gözü, R. Oktay
AAI-3169-2021
AAG-8744-2021
AAD-1271-2019
AAL-8873-2021
Source :
Lung. 185:309-314
Publication Year :
2007
Publisher :
Springer Science and Business Media LLC, 2007.

Abstract

The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.

Details

ISSN :
14321750 and 03412040
Volume :
185
Database :
OpenAIRE
Journal :
Lung
Accession number :
edsair.doi.dedup.....237eec3fc2b144626f4c15b6372a47ed
Full Text :
https://doi.org/10.1007/s00408-007-9026-x