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Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow
- Source :
- Neumann, K T, Klimczyk, S, Burhardt, M, Bang-Andersen, B, Skrydstrup, T & Lindhardt, A T 2016, ' Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow ', ACS Catalysis, vol. 6, no. 7, pp. 4710-4714 . https://doi.org/10.1021/acscatal.6b01045
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of functional groups, are carried out in a two-chamber setup with ex situ generated hydrogen. The reaction setup is highly suitable for deuterium labeling. The trans-selective hydrogenation was extrapolated to a transfer hydrogenation protocol, employing a packed bed immobilized ruthenium hydride catalyst in continuous flow with a retention time of only 10 min.
- Subjects :
- inorganic chemicals
Packed bed
Hydrogen
010405 organic chemistry
Chemistry
Hydride
Inorganic chemistry
Noyori asymmetric hydrogenation
chemistry.chemical_element
General Chemistry
010402 general chemistry
Photochemistry
Transfer hydrogenation
01 natural sciences
Catalysis
0104 chemical sciences
Ruthenium
Deuterium
otorhinolaryngologic diseases
Subjects
Details
- ISSN :
- 21555435
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS Catalysis
- Accession number :
- edsair.doi.dedup.....23892078cd336d33ed73709559392f3c