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The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score
- Source :
- Journal of Cardiovascular Translational Research, 14(5), 992-1000. Springer New York, Journal of Cardiovascular Translational Research
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract
- Subjects :
- Male
Automated quantification
medicine.medical_treatment
Pharmaceutical Science
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Severity of Illness Index
Coronary calcification
Coronary artery disease
Automation
0302 clinical medicine
Risk Factors
Intravascular ultrasound
Myocardial Revascularization
Clinical endpoint
Myocardial infarction
Stroke
Genetics (clinical)
0303 health sciences
medicine.diagnostic_test
Hazard ratio
Middle Aged
Prognosis
Cohort
Disease Progression
Cardiology
Molecular Medicine
Female
Original Article
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Revascularization
Risk Assessment
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Image Interpretation, Computer-Assisted
Genetics
medicine
Humans
Vascular Calcification
Ultrasonography, Interventional
Aged
Retrospective Studies
030304 developmental biology
business.industry
Reproducibility of Results
medicine.disease
business
Subjects
Details
- ISSN :
- 19375395 and 19375387
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Translational Research
- Accession number :
- edsair.doi.dedup.....23b89bb4e54a765b07f01a3a21c92485