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G-quadruplex in cancer biology and drug discovery
G-quadruplex in cancer biology and drug discovery
- Source :
- Biochemical and Biophysical Research Communications. 531:45-50
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- G-quadruplex (G4) is a non-canonical nucleic acid structure formed in guanine-rich DNA or RNA. G4s are formed not only in vitro but also in vivo and are attracting considerable interest owing to their potential involvement in biological processes, including replication, transcription, mRNA splicing, translation and epigenetic regulation of the genome. In this review, we outline the functions of G4 in cellular biology and their implication in human pathogenesis, especially in cancer. Furthermore, we describe the properties of G4-stabilizing chemical compounds, G4 ligands, and their application for cancer therapeutics.
- Subjects :
- 0301 basic medicine
Biophysics
Antineoplastic Agents
Computational biology
Biology
G-quadruplex
Biochemistry
Epigenesis, Genetic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Transcription (biology)
Neoplasms
Drug Discovery
Animals
Humans
Epigenetics
Nucleic acid structure
Molecular Biology
Drug discovery
RNA
DNA
Cell Biology
G-Quadruplexes
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
RNA splicing
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 531
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....23b9ac5acceba3bd839c34e6f81bc6d9
- Full Text :
- https://doi.org/10.1016/j.bbrc.2020.03.178