Back to Search Start Over

G-quadruplex in cancer biology and drug discovery

G-quadruplex in cancer biology and drug discovery

Authors :
Chuya Nakanishi
Hiroyuki Seimiya
Source :
Biochemical and Biophysical Research Communications. 531:45-50
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

G-quadruplex (G4) is a non-canonical nucleic acid structure formed in guanine-rich DNA or RNA. G4s are formed not only in vitro but also in vivo and are attracting considerable interest owing to their potential involvement in biological processes, including replication, transcription, mRNA splicing, translation and epigenetic regulation of the genome. In this review, we outline the functions of G4 in cellular biology and their implication in human pathogenesis, especially in cancer. Furthermore, we describe the properties of G4-stabilizing chemical compounds, G4 ligands, and their application for cancer therapeutics.

Details

ISSN :
0006291X
Volume :
531
Database :
OpenAIRE
Journal :
Biochemical and Biophysical Research Communications
Accession number :
edsair.doi.dedup.....23b9ac5acceba3bd839c34e6f81bc6d9
Full Text :
https://doi.org/10.1016/j.bbrc.2020.03.178