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Insertions and Deletions Play an Important Role in the Diversity of Conotoxins
- Source :
- The protein journal. 39(2)
- Publication Year :
- 2020
-
Abstract
- Previous studies have indicated that each conotoxin precursor has a hyperconserved signal region, a rather conserved pro region and a hypervariable mature region, and nucleotide mutations are the main driven factor. However, in this study, we made an in-depth analysis on the M-superfamily conotoxin precursors and found that the diversity of the signal, pro and mature regions are more complicated than previous findings. Different conotoxin precursors can have same signal, pro and/or mature regions, especially different conotoxin precursors with same mature region but different signal and pro regions. In addition, insertions and deletions (indels) were detected in conotoxin precursors. Indels are infrequent in the signal region but frequent in the pro and mature regions. In contrast to deletions that dominate in the pro region, insertions dominate in the mature region. The number of amino acids is crucial for the physiological functions of mature conotoxins, therefore indels, especially insertions in the mature region, play an important role in the sequence and function diversity of conotoxins.
- Subjects :
- Signal region
Bioengineering
Pro region
Biology
complex mixtures
Biochemistry
Analytical Chemistry
Cone snail
03 medical and health sciences
INDEL Mutation
Animals
Nucleotide
Conotoxin
Amino Acid Sequence
Indel
030304 developmental biology
chemistry.chemical_classification
Genetics
0303 health sciences
030302 biochemistry & molecular biology
Organic Chemistry
Conus Snail
food and beverages
Amino acid
nervous system
chemistry
Conotoxins
Function (biology)
Subjects
Details
- ISSN :
- 18758355
- Volume :
- 39
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The protein journal
- Accession number :
- edsair.doi.dedup.....23da9a52bcf442e6dd1cf83727d68fe0