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Hepatitis D virus and liver transplantation: Indications and outcomes

Hepatitis D virus and liver transplantation: Indications and outcomes

Authors :
Muhammad Baraa Hammami
Aniqa Tehreem
Peng-Sheng Ting
Haris Muhammad
Ramzan Idilman
Ahmet Gurakar
Source :
World Journal of Hepatology
Publication Year :
2021
Publisher :
Baishideng Publishing Group Inc., 2021.

Abstract

Hepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV and hepatitis B virus coinfection is uncommon in the United States, most data on the long-term impact of LT on HDV are from international centers. In this review, we discuss the indications and results of LT with treatment options in HDV patients.

Details

ISSN :
19485182
Volume :
13
Database :
OpenAIRE
Journal :
World Journal of Hepatology
Accession number :
edsair.doi.dedup.....23de07a1e66db2bbd0ee97359cf28b85
Full Text :
https://doi.org/10.4254/wjh.v13.i3.291