Back to Search
Start Over
CD105 (endoglin), apoptosis, and stroke
- Source :
- Scopus-Elsevier
-
Abstract
- To the Editor: The recent paper by Zhu et al1 in this journal provides an insight into the possible mechanism of hypoxia-induced upregulation of CD105 (endoglin). The following 3 points are relevant to their paper. Lately there has been a major debate regarding the relevance of cell culture/animal models for human stroke in general and for angiogenesis in particular. Some authors maintain that the failure of current therapies for stroke in humans based on the use of animal models is possibly owing to the fact that the pathobiology of human stroke is not mirrored by experimentally-induced stroke in animal models. If true, it would limit the value findings of Zhu et al,1 which are based on the use of murine endothelial cell culture and an in vivo mouse model of focal cerebral ischemia. However, there is strong evidence to discount this possibility. First, CD105 has been found …
- Subjects :
- Angiogenesis
Ischemia
Vascular Cell Adhesion Molecule-1
Apoptosis
Receptors, Cell Surface
Models, Biological
Mice
Downregulation and upregulation
Antigens, CD
Medicine
Animals
Humans
Smad3 Protein
Stroke
Cells, Cultured
Advanced and Specialized Nursing
Neovascularization, Pathologic
Mechanism (biology)
business.industry
Pregnancy-Specific beta 1-Glycoproteins
Endoglin
medicine.disease
Hypoxia-Inducible Factor 1, alpha Subunit
Cell Hypoxia
Up-Regulation
DNA-Binding Proteins
Disease Models, Animal
Cell culture
Trans-Activators
Neurology (clinical)
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Neuroscience
Transcription Factors
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....23def84349e02500193ffed7a111655c