Development of a series of flurbiprofen and zaltoprofen platinum(<scp>iv</scp>) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA

To develop new anti-metastasis chemotherapeutic drugs, a series of flurbiprofen (FLP) and zaltoprofen (ZTP) platinum(IV) complexes targeting COX-2, PD-L1 and DNA was prepared and investigated. Complex 2 with dual FLP ligands displays promising antitumor activities