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Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?
Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?
- Source :
- Current Pharmaceutical Design. 27:2796-2801
- Publication Year :
- 2021
- Publisher :
- Bentham Science Publishers Ltd., 2021.
-
Abstract
- Background & Objective: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called “antioxidant paradox” phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful. Method: The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported. Conclusion: In this setting, we acknowledge that there is an urgent need for more elaborate studies in the future that will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential.
- Subjects :
- Male
Pharmacology
medicine.medical_specialty
business.industry
media_common.quotation_subject
Scopus
Fertility
medicine.disease
Antioxidants
Male infertility
Oxidative Stress
Semen
Drug Discovery
medicine
Humans
Risks and benefits
Reactive Oxygen Species
Intensive care medicine
business
Infertility, Male
media_common
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....240eff68c4accd40de67755df5fd9823
- Full Text :
- https://doi.org/10.2174/1381612827666210204160248