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Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?

Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?

Authors :
Atsushi Takenaka
Georgios Hatzichristodoulou
A. Zachariou
Nikolaos Sofikitis
Ioannis Sokolakis
Panagiota Tsounapi
Evangelos N. Symeonidis
Aris Kaltsas
Fotios Dimitriadis
Source :
Current Pharmaceutical Design. 27:2796-2801
Publication Year :
2021
Publisher :
Bentham Science Publishers Ltd., 2021.

Abstract

Background & Objective: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called “antioxidant paradox” phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful. Method: The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported. Conclusion: In this setting, we acknowledge that there is an urgent need for more elaborate studies in the future that will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential.

Details

ISSN :
13816128
Volume :
27
Database :
OpenAIRE
Journal :
Current Pharmaceutical Design
Accession number :
edsair.doi.dedup.....240eff68c4accd40de67755df5fd9823
Full Text :
https://doi.org/10.2174/1381612827666210204160248