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Chemical and biological profiles of Tussilago farfara: Structures, nitric oxide inhibitory activities, and interactions with iNOS protein
- Source :
- Journal of Functional Foods, Vol 32, Iss, Pp 37-45 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Tussilago farfara L. is a well-known herb plant and used widely in China, North Africa, and Europe. A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of three new sesquiterpenes, one new phenolic derivative, and ten known compounds from the flower buds of T. farfara . Their structures were established on the basis of extensive analyses of nuclear magnetic resonance (NMR) spectroscopic data. All of the isolates exhibited inhibitory effects on LPS-induced NO production in BV-2 cells. The possible mechanism of NO inhibition was also investigated using molecular docking, which revealed the interactions of bioactive compounds with iNOS protein. The present study disclosed that flower buds of T. farfara have the potential to be developed into a functional food.
- Subjects :
- food.ingredient
Stereochemistry
Medicine (miscellaneous)
Biology
Inhibitory postsynaptic potential
01 natural sciences
Nitric oxide
chemistry.chemical_compound
food
Functional food
TX341-641
No production
Inos protein
Flower buds
Nutrition and Dietetics
010405 organic chemistry
Nutrition. Foods and food supply
NO inhibitory effects
Tussilago farfara
biology.organism_classification
0104 chemical sciences
iNOS
010404 medicinal & biomolecular chemistry
Tussilago
Biochemistry
Phytochemical
chemistry
Herb
Molecular docking
Sesquiterpenes
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....241242ad77c490f133fe985542d0ca54