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Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics
- Source :
- Lab on a Chip. 18:1690-1703
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry (RSC), 2018.
-
Abstract
- Study of extracellular vesicles (EVs), particularly exosomes, holds significant promise; however, it is technically challenging to define these small and molecularly diverse nanovesicles. With intrinsic molecular payload and biodegradability, molecular engineering of exosomes opens new avenues for mediating cellular responses and developing novel nano-delivery systems in precision therapeutics. Microfluidic lab-on-chip technology is playing pivotal roles in this emerging field. In this review, we have examined scientific advancements of microfluidic technology for engineering exosomes and assessed future applications and perspectives in developing precision therapeutics; this can serve the community via identification of potential new research areas or technologies that are urgently needed in precision therapeutics.
- Subjects :
- 0301 basic medicine
Extramural
Research areas
Computer science
Microfluidics
Biomedical Engineering
Bioengineering
Nanotechnology
General Chemistry
Microfluidic Analytical Techniques
Exosomes
Biochemistry
Extracellular vesicles
Article
Microvesicles
Cell Line
Molecular engineering
Mice
03 medical and health sciences
030104 developmental biology
Lab-On-A-Chip Devices
Animals
Humans
Biotechnology
Subjects
Details
- ISSN :
- 14730189 and 14730197
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Lab on a Chip
- Accession number :
- edsair.doi.dedup.....2419561c4ff39714429d735e4f4011b8