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Dendritic cell-based immunotherapy of malignant melanoma: success and limitations
- Source :
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 5(3)
- Publication Year :
- 2007
-
Abstract
- Dendritic cells (DC) are professional antigen-presenting cells in the immune system which are able to induce primary T-cell responses. Because of their central role in the initiation of immune responses, DC are an important tool for tumor-antigen-specific immunotherapy of cancer. DC vaccination using tumor-antigen-loaded DC has led to tumor regression in individual advanced-stage cancer patients. However, there is a discrepancy between strong and antigen-specific T cell responses in vaccinated cancer patients detectable ex vivo and only weak clinical responses. In most cases the immune system of advanced stage IV cancer patients allows only a temporary anti-tumor response and increasing evidence exists that active suppressive mechanisms of the immune system as well as of the tumor itself ultimately prevent "autoaggressive" immune reactions against the tumor. Active counter-regulation of effector T cells by tumor-antigen-specific regulatory T-cell (Treg) populations play a central role in limiting the efficacy of the vaccines. Nevertheless, recent studies have shown that DC,additionally activated byToll-Like-receptor ligands (TLRL) can neutralize these suppressive effects of Treg and facilitate the induction of long-lasting effector T cell responses even in the presence of activated Treg. These studies open a new way for "conditioning" of DC by TLRL and might significantly enhance the efficiency of DC-based melanoma vaccines in the future.
- Subjects :
- Skin Neoplasms
Effector
T cell
medicine.medical_treatment
Melanoma
Models, Immunological
Cancer
Dermatology
Immunotherapy
Dendritic cell
Dendritic Cells
Biology
medicine.disease
Immunotherapy, Adoptive
Melanoma Vaccine
medicine.anatomical_structure
Immune system
Treatment Outcome
Immunology
Practice Guidelines as Topic
medicine
Humans
Practice Patterns, Physicians'
Subjects
Details
- Language :
- German
- ISSN :
- 16100387
- Volume :
- 5
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
- Accession number :
- edsair.doi.dedup.....2472c733b0f7fd5a923b7e8a439c5468