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FMC-HU-1-B: a lymphoma B-cell line with unusual characteristics
- Source :
- Leukemia research. 9(1)
- Publication Year :
- 1985
-
Abstract
- A cell line (FMC-Hu-1-B) was established from a biopsy of an abdominal mass of a child with non-Burkitt's lymphoma. The establishment of the cell line initially required the presence of normal bone marrow stromal cells and phytohaemagglutinin stimulated leucocyte conditioned medium. The cell line lacked Epstein-Barr virus nuclear antigen and exhibited numerous chromosomal abnormalities. Cell-surface marker analysis using a panel of monoclonal antibodies revealed only markers of the B lineage. Within the B-cell lineage FMC-Hu-1-B seemed to occupy a level of maturation equivalent to normal mature B-cells (surface membrane IgM, secretion of immunoglobulin and FMC-1 positive). However, the cells also weakly expressed the common acute lymphoblastic leukaemia antigen, normally found on early precursors of B-cells. The cells appear to secrete auto-stimulatory growth factor(s).
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Stromal cell
Lymphoma
medicine.drug_class
Receptors, Antigen, B-Cell
Monoclonal antibody
Major histocompatibility complex
Cell Line
Antigen
medicine
Humans
B-cell lymphoma
Child
Chromosome Aberrations
B-Lymphocytes
biology
Hematology
medicine.disease
Molecular biology
Phenotype
Oncology
Cell culture
biology.protein
Antibody
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Leukemia research
- Accession number :
- edsair.doi.dedup.....2482a73356d9e7072ca16820f48cdef6