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A Randomized Controlled Trial of Interventions for Growth Suppression in Children With Attention-Deficit/Hyperactivity Disorder Treated With Central Nervous System Stimulants
- Source :
- Journal of the American Academy of Child and Adolescent Psychiatry, vol 59, iss 12
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- ObjectiveTo examine the impact of central nervous system (CNS) stimulants on the growth of children with attention-deficit/hyperactivity disorder (ADHD), and to assess the efficacy and feasibility of weight recovery interventions on growth.MethodA total of 230 children aged 5 to 12 years with ADHD with no history of chronic CNS stimulant use were randomly assigned to receive daily CNS stimulants (78%, primarily osmotic release oral system-methylphenidate [OROS-MPH]) or behavioral treatment (22%) for 30 months. After 6 months, children evidencing a decline in body mass index (BMI) of >0.5 z-units were randomized to 1 of 3 weight recovery treatments (WRTs): monthly monitoring of height/weight (MON) plus continued daily medication; drug holidays (DH) with medication limited to school days; or daily caloric supplementation (CS) with a 150-kcal supplement plus daily medication.ResultsBefore WRT assignment, medication was associated with significant reductions in standardized weight and height (p values&nbsp
- Subjects :
- Pediatrics
medicine.medical_treatment
Psychological intervention
Medical and Health Sciences
law.invention
Body Mass Index
Randomized controlled trial
law
Developmental and Educational Psychology
Child
Pediatric
05 social sciences
Drug holiday
Psychiatry and Mental health
medicine.anatomical_structure
Treatment Outcome
Mental Health
Child, Preschool
6.1 Pharmaceuticals
050104 developmental & child psychology
medicine.medical_specialty
growth
Central nervous system
Clinical Trials and Supportive Activities
Developmental & Child Psychology
CNS stimulants
attention-deficit/hyperactivity disorder
Clinical Research
medicine
Attention deficit hyperactivity disorder
Humans
0501 psychology and cognitive sciences
Obesity
Preschool
Nutrition
business.industry
Prevention
Body Weight
Psychology and Cognitive Sciences
Neurosciences
Evaluation of treatments and therapeutic interventions
medicine.disease
Attention Deficit Hyperactivity Disorder (ADHD)
Stimulant
Clinical trial
Good Health and Well Being
Attention Deficit Disorder with Hyperactivity
Methylphenidate
Central Nervous System Stimulants
business
Body mass index
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry, vol 59, iss 12
- Accession number :
- edsair.doi.dedup.....248c20d1b6ffa6e5cb4fa300a683e363