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Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1

Authors :
Mona Patel
Haiyan Bian
Geoffrey G. Cox
Keith T. Demarest
Maud Urbanski
Mary Pat Beavers
Philip J. Rybczynski
Bruce R. Conway
Xiaoyan Zhang
Roxanne E. Zeck
Source :
Bioorganicmedicinal chemistry letters. 15(23)
Publication Year :
2005

Abstract

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.

Details

ISSN :
0960894X
Volume :
15
Issue :
23
Database :
OpenAIRE
Journal :
Bioorganicmedicinal chemistry letters
Accession number :
edsair.doi.dedup.....248d4258cce6e9b65c627f37ee9aa4ca