Back to Search
Start Over
Effects of nutritional programing on growth and metabolism caused by albumen removal in an avian model
- Publication Year :
- 2015
- Publisher :
- BRISTOL, 2015.
-
Abstract
- In mammalian models of prenatal undernutrition the maternal diet is manipulated, exerting both nutritional and hormonal effects on the offspring. In contrast, in the chicken, strictly nutritional effects can be applied. Prenatal protein undernutrition in chickens was induced by partial replacement of albumen with saline during early embryonic development (albumen-deprived group) and results were compared with a sham-manipulated and a non-manipulated group. Body weight of the albumen-deprived hens was reduced throughout the entire experimental period (0-55 weeks). The reproductive capacity was diminished in the albumen-deprived hens as reflected in the reduced number of eggs and lower egg weight. The plasma triiodothyronine levels were increased in the albumen-deprived group compared with the non-manipulated hens, but not the sham-manipulated hens. An oral glucose tolerance test (OGTT) at 10 weeks of age revealed a decreased glucose tolerance in the albumen-deprived hens. During adulthood, an age-related loss of glucose tolerance was observed in the hens, leading to disappearance of treatment differences in the OGTT. The offspring of the albumen-deprived hens (PA chicks) had reduced body weight until at least 3 weeks of age. In addition, the PA chicks had a decreased relative residual yolk weight at hatching. An insulin tolerance test revealed increased sensitivity to insulin for the PA chicks compared with the offspring of the non-manipulated (PN) and sham-manipulated hens (PS). In conclusion, prenatal protein undernutrition by albumen removal caused long-term effects on body weight, reproductive performance, and physiology. ispartof: Journal of Endocrinology vol:225 issue:2 pages:89-100 ispartof: location:England status: published
- Subjects :
- Male
medicine.medical_specialty
food.ingredient
Offspring
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Carbohydrate metabolism
Biology
reproduction
Endocrinology
food
prenatal protein undernutrition
Pregnancy
Albumins
Internal medicine
Yolk
medicine
Animals
Humans
Insulin
Glucose homeostasis
glucose homeostasis
Prenatal Nutritional Physiological Phenomena
Ovum
Reproduction
Body Weight
Insulin tolerance test
medicine.disease
Glucose
Prenatal Exposure Delayed Effects
Models, Animal
Decreased glucose tolerance
chickens
Female
Chickens
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....24992bc602d67cb0f8cbfb993ad0be62