Additional file 1 of Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration

Additional file 1: Supplementary Table 1. Demographics and diagnoses of all individual cases and controls. Supplementary Fig. 1. Microglial burden compared between grey and white matter within each lobe for each group. Comparisons of the burden of CD68-positive (a, d, g, j, m, p), CR3/43-positive (b, e, h, k, n, q), and Iba1-positive (c, f, i, l, o, r) microglia for each group comparison level shown within Fig. 1 (numbers in coloured circles on left represent level of comparison). Graphs show median microglial burden (percentage area values) compared within lobes: frontal grey (FG) versus frontal white (FW) matter, and temporal grey (TG) versus temporal white (TW) matter. See legend in first graph on each row for bar colours. Error bars represent interquartile range. *p < 0.05; **p < 0.01; ***p ≤ 0.001; ****p ≤ 0.0001. Supplementary Fig. 2. Microglial circularity compared between grey and white matter within each lobe for each group. Comparisons of the circularity of CD68-positive (a, d, g, j, m, p), CR3/43-positive (b, e, h, k, n, q), and Iba1-positive (c, f, i, l, o, r) microglia for each group comparison level shown within Fig. 1 (numbers in coloured circles on left represent level of comparison). Graphs show median circularity values compared within lobes: frontal grey (FG) versus frontal white (FW) matter, and temporal grey (TG) versus temporal white (TW) matter. See legend in first graph on each row for bar colours. Error bars represent interquartile range. *p < 0.05; **p < 0.01; ***p ≤ 0.001; ****p ≤ 0.0001. Supplementary Fig. 3. Microglial perimeter compared between grey and white matter within each lobe for each group. Comparisons of the perimeter of CD68-positive (a, d, g, j, m, p), CR3/43-positive (b, e, h, k, n, q), and Iba1-positive (c, f, i, l, o, r) microglia for each group comparison level shown within Fig. 1 (numbers in coloured circles on left represent level of comparison). Graphs show median perimeter values compared within lobes: frontal grey (FG) versus frontal white (FW) matter, and temporal grey (TG) versus temporal white (TW) matter. See legend in first graph on each row for bar colours. Error bars represent interquartile range. *p < 0.05; **p < 0.01; ***p ≤ 0.001; ****p ≤ 0.0001