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Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications
- Source :
- Stem Cell Research, Vol 49, Iss, Pp 102109-(2020)
- Publication Year :
- 2020
-
Abstract
- Retinopathy is a well-known ocular complication that occurs in patients with type 2 diabetes (T2D). Recent evidence also indicates that diabetic patients have an increased prevalence of dry eye syndrome. However, the etiologies of both diabetic retinopathy (DR) and dry eye disease are complex, and their associations with T2D remains to be fully understood. Patient-derived human induced pluripotent stem cells (hiPSCs) enable the generation of disease-specific retinal tissues such as retinal pigment epithelium and lacrimal gland to model disease pathogenesis. Here, we describe the establishment of three hiPSC lines from T2D patients with PDR or dry eye disease.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
endocrine system diseases
Induced Pluripotent Stem Cells
Type 2 diabetes
Lacrimal gland
Retinal Pigment Epithelium
Biology
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
Induced pluripotent stem cell
lcsh:QH301-705.5
Retinal pigment epithelium
Diabetic Retinopathy
Retinal
Cell Biology
General Medicine
Diabetic retinopathy
medicine.disease
eye diseases
030104 developmental biology
medicine.anatomical_structure
chemistry
lcsh:Biology (General)
Diabetes Mellitus, Type 2
sense organs
030217 neurology & neurosurgery
Developmental Biology
Retinopathy
Subjects
Details
- ISSN :
- 18767753
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Stem cell research
- Accession number :
- edsair.doi.dedup.....24d1256a598b41e81630cbfe45e5692b