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Synthesis, structures, and biological studies of heterobimetallic Au(I)-Ru(II) complexes involving N-heterocyclic carbene-based multidentate ligands
- Source :
- Organometallics, Organometallics, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩, Organometallics, American Chemical Society, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩
- Publication Year :
- 2015
-
Abstract
- International audience; Three heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-N-heterocyclic carbene (NHC) ligands were synthesized and fully characterized by spectroscopic methods and in one case by single-crystal X-ray diffraction. In addition, the in vitro cytotoxic, antileishmanial, and antimalarial activities of these new heterobimetallic complexes were assessed. Moreover, the photophysical properties of two compounds have been used to localize them in tumor cells by confocal microscopy.
- Subjects :
- STEPWISE METALATION STRATEGY
Denticity
RUTHENIUM(II) COMPLEXES
Stereochemistry
THIOREDOXIN REDUCTASE
chemistry.chemical_element
Tumor cells
IN-VITRO EVALUATION
law.invention
Inorganic Chemistry
chemistry.chemical_compound
Confocal microscopy
law
[CHIM.COOR]Chemical Sciences/Coordination chemistry
Physical and Theoretical Chemistry
DINUCLEAR GOLD(I)
Biological studies
Organic Chemistry
Combinatorial chemistry
In vitro
QUADRUPLEX DNA
3. Good health
Ruthenium
chemistry
TRICARBENE LIGAND
ANTICANCER AGENTS
GOLD(III) COMPLEXES
CYTOTOXIC METALLODRUGS
Carbene
Subjects
Details
- ISSN :
- 02767333 and 15206041
- Database :
- OpenAIRE
- Journal :
- Organometallics, Organometallics, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩, Organometallics, American Chemical Society, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩
- Accession number :
- edsair.doi.dedup.....24e47a7266bc7d6b781d7540801e2a91
- Full Text :
- https://doi.org/10.1021/om501158m⟩