Percent survival of wild-type and Hif-1��-/- larval zebrafish in normoxia and intermittent hypoxia with and without access to the surface. from Aquatic surface respiration improves survival during hypoxia in zebrafish (Danio rerio) lacking hypoxia-inducible factor 1-��

Figure S2. Percent survival of wild-type and Hif-1��-/- larval zebrafish in normoxia and intermittent hypoxia with and without access to the surface. Larval zebrafish were exposed to normoxia (A, C, F), or intermittent hypoxia (16 mmHg for 4 h per day) without access to the surface (D, G), or with access to the surface (B,E, H). Individuals of each genotype were tested from 1 to 5 days post fertilization (dpf) (A,B), 5 to 9 dpf (C-E), and 12 to 16 dpf (F-H). Data points to the left of the dashed line represent survival at the onset of experiment and the first data point to the right of the dashed line represents survival following first hypoxic bout or equivalent time for fish that remained in normoxia. Larval zebrafish from 1 to 5 dpf were not tested in intermittent hypoxia without access to the surface. Statistical analysis are presented in Figure 3. Data are presented as means��s.e.m.