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The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases

Authors :
Anne Marie Miller
Anja Schneider
Tomasz Gabryelewicz
Marcel M. Verbeek
Lucilla Parnetti
Tormod Fladby
Alexandre de Mendonça
Charlotte E. Teunissen
Fay Betsou
Uroš Rot
Walter Maetzler
Henrik Zetterberg
Frederic Brosseron
Sylvain Lehmann
Alberto Lleó
José Luis Molinuevo
Luka Kulic
Anja Hviid Simonsen
Frans R.J. Verhey
Enrica Cavedo
Philip Scheltens
Peter Koson
Hakan Gurvit
Babette L.R. Reijs
Inês Baldeiras
Piotr Lewczuk
Lutz Froelich
Brit Mollenhauer
Elisabeth Kapaki
Bengt Winblad
Fabrizio Tagliavini
Kaj Blennow
Magda Tsolaki
Nikolai Goncharenko
Pieter Jelle Visser
Marzena Zboch
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Promovendi MHN
Hersenen & Gedrag
Psychiatrie & Neuropsychologie
MUMC+: MA Med Staf Spec Psychiatrie (9)
RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience
Clinical chemistry
Neurology
NCA - neurodegeneration
Source :
Frontiers in Neurology, Frontiers in Neurology, Frontiers, 2015, 6, ⟨10.3389/fneur.2015.00216⟩, Frontiers in Neurology, 6, Frontiers in Neurology, 6:216. Frontiers Media S.A., Frontiers in Neurology.-Lausanne : Frontiers Media SA; 2015.-S.216:1-216:7., Frontiers in Neurology, Vol 6 (2015), Reijs, B L R, Teunissen, C E, Goncharenko, N, Betsou, F, Blennow, K, Baldeiras, I, Brosseron, F, Cavedo, E, Fladby, T, Froelich, L, Gabryelewicz, T, Gurvit, H, Kapaki, E, Koson, P, Kulic, L, Lehmann, S, Lewczuk, P, Lleo, A, Maetzler, W, de Mendonca, A, Miller, A M, Molinuevo, J L, Mollenhauer, B, Parnetti, L, Rot, U, Schneider, A, Simonsen, A H, Tagliavini, F, Tsolaki, M, Verbeek, M M, Verhey, F R J, Zboch, M, Winblad, B, Scheltens, P, Zetterberg, H & Visser, P J 2015, ' The central biobank and virtual biobank of BiOMarKaPD: a resource for studies on neurodegenerative diseases ', Frontiers in Neurology, vol. 6, 216 . https://doi.org/10.3389/fneur.2015.00216, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Frontiers in neurology 6, 216 (2015). doi:10.3389/fneur.2015.00216, FRONTIERS IN NEUROLOGY
Publication Year :
2015
Publisher :
Frontiers Media S.A., 2015.

Abstract

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank. © 2015 Reijs, Teunissen, Goncharenko, Betsou, Blennow, Baldeiras, Brosseron, Cavedo, Fladby, Froelich, Gabryelewicz, Gurvit, Kapaki, Koson, Kulic, Lehmann, Lewczuk, Lleó, Maetzler, de Mendonça, Miller, Molinuevo, Mollenhauer, Parnetti, Rot, Schneider, Simonsen, Tagliavini, Tsolaki, Verbeek, Verhey, Zboch, Winblad, Scheltens, Zetterberg and Visser.

Details

Language :
English
ISSN :
16642295
Volume :
6
Database :
OpenAIRE
Journal :
Frontiers in Neurology
Accession number :
edsair.doi.dedup.....25028609cdf8e00930dd92b9add30835