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The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases
- Source :
- Frontiers in Neurology, Frontiers in Neurology, Frontiers, 2015, 6, ⟨10.3389/fneur.2015.00216⟩, Frontiers in Neurology, 6, Frontiers in Neurology, 6:216. Frontiers Media S.A., Frontiers in Neurology.-Lausanne : Frontiers Media SA; 2015.-S.216:1-216:7., Frontiers in Neurology, Vol 6 (2015), Reijs, B L R, Teunissen, C E, Goncharenko, N, Betsou, F, Blennow, K, Baldeiras, I, Brosseron, F, Cavedo, E, Fladby, T, Froelich, L, Gabryelewicz, T, Gurvit, H, Kapaki, E, Koson, P, Kulic, L, Lehmann, S, Lewczuk, P, Lleo, A, Maetzler, W, de Mendonca, A, Miller, A M, Molinuevo, J L, Mollenhauer, B, Parnetti, L, Rot, U, Schneider, A, Simonsen, A H, Tagliavini, F, Tsolaki, M, Verbeek, M M, Verhey, F R J, Zboch, M, Winblad, B, Scheltens, P, Zetterberg, H & Visser, P J 2015, ' The central biobank and virtual biobank of BiOMarKaPD: a resource for studies on neurodegenerative diseases ', Frontiers in Neurology, vol. 6, 216 . https://doi.org/10.3389/fneur.2015.00216, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Frontiers in neurology 6, 216 (2015). doi:10.3389/fneur.2015.00216, FRONTIERS IN NEUROLOGY
- Publication Year :
- 2015
- Publisher :
- Frontiers Media S.A., 2015.
-
Abstract
- Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank. © 2015 Reijs, Teunissen, Goncharenko, Betsou, Blennow, Baldeiras, Brosseron, Cavedo, Fladby, Froelich, Gabryelewicz, Gurvit, Kapaki, Koson, Kulic, Lehmann, Lewczuk, Lleó, Maetzler, de Mendonça, Miller, Molinuevo, Mollenhauer, Parnetti, Rot, Schneider, Simonsen, Tagliavini, Tsolaki, Verbeek, Verhey, Zboch, Winblad, Scheltens, Zetterberg and Visser.
- Subjects :
- Oncology
cognition
Pathology
Parkinson's disease
[SDV]Life Sciences [q-bio]
frontotemporal dementia
lcsh:RC346-429
Faculty of Medicine
Medizinische Fakultät
diffuse Lewy body disease
Biomarker discovery
ComputingMilieux_MISCELLANEOUS
Original Research
Alzheimer's disease
biological marker
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
Biobank
3. Good health
multiinfarct dementia
Parkinson disease
biobank
Neurology
neurodegenerative disorders
Alzheimer's disease (AD)
prognostic assessment
blood sampling
diagnostic procedure
cerebrospinal fluid
dementia
Alzheimer’s disease
Parkinson’s disease
body fluids
Alzheimer disease
Frontotemporal dementia
medicine.medical_specialty
Article
Progressive supranuclear palsy
mild cognitive impairment
Internal medicine
mental disorders
medicine
ddc:6
Dementia
degenerative disease
ddc:610
Body fluids
Cerebrospinal fluid
Neurodegenerative disorders
Neurology (clinical)
Vascular dementia
plasma
lcsh:Neurology. Diseases of the nervous system
standardization
body fluid
business.industry
Dementia with Lewy bodies
health care facility
progressive supranuclear palsy
assay
medicine.disease
validation process
Shy Drager syndrome
business
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 16642295
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....25028609cdf8e00930dd92b9add30835