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Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetes
- Source :
- Cytokine. 34(5-6)
- Publication Year :
- 2006
-
Abstract
- Background Even though the gene encoding for IGF-I is considered of most importance amongst blood pressure-regulating genes in mouse models, little and discordant data are available in literature for what concerns a possible relationship between blood pressure and serum free IGF-I values in humans. In addition, no information is available on type 1 diabetes patients. Aim: Our aim is to analyze the relationship between systolic and diastolic blood pressure and serum free IGF-I and IGFBP-3 levels in subjects suffering from type 1 diabetes. Results: A highly significant inverse correlation was observed between serum free IGF-I levels and both systolic and diastolic blood pressure in subjects affected with type 1 diabetes. Similar but less significant relationships were observed for IGFBP-3, whose levels were also significantly and directly correlated with those of free IGF-I. The correlation between systolic and diastolic blood pressures with free IGF-I and between systolic blood pressure and IGFBP-3 levels were confirmed after adjusting for age, gender, age at diagnosis, disease duration, familial history, HBA1c, and amount of insulin administered by multivariate logistic regression analysis. A decrease in free IGF-I and IGFBP-3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications, confirming how these molecules may be considered as severity markers for patients with type 1 diabetes as well as risk factors for altered pressure control linked diseases.
- Subjects :
- Adult
Male
Serum
medicine.medical_specialty
medicine.medical_treatment
Immunology
Diastole
Blood Pressure
Logistic regression
Biochemistry
Prehypertension
Correlation
Internal medicine
medicine
Immunology and Allergy
Humans
Insulin-Like Growth Factor I
Inverse correlation
Molecular Biology
Type 1 diabetes
business.industry
Insulin
Hematology
medicine.disease
Blood pressure
Endocrinology
Diabetes Mellitus, Type 1
Insulin-Like Growth Factor Binding Protein 3
Female
business
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 34
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....2517269ceebf57473cf00b7e07d4a33e