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A comparison of MyPKFiT and WAPPS-Hemo as dosing tools for optimizing prophylaxis in patients with severe haemophilia A treated with Octocog alfa
- Source :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES. 27(3)
- Publication Year :
- 2021
-
Abstract
- Introduction: MyPKFiT and the Web-Accessible Population Pharmacokinetic service—Hemophilia (WAPPS-Hemo) are web-based population-based applications developed for helping physicians individualize and optimize replacement therapy. Although MyPKFiT is intended for Octocog alfa and Rurioctocog alfa pegol use only, the WAPPS-Hemo is applicable to all factor VIII concentrates. Aim: To compare MyPKFiT and WAPPS-Hemo as dosing tools for optimizing treatment of patients with severe haemophilia A on regular prophylaxis with Octocog alfa in a real-world setting. Methods: Fourteen patients with severe haemophilia A (median age 30.8 years; range 20–71) were enrolled. The FVIII activity was measured twice after a regular dose of Octocog alfa by the chromogenic and the one-stage assays. PK analyses were performed using each tool and dosing estimations to reach trough levels of 1%, 3% or 5% after 48 h. Findings were calculated and compared. Results: The two PK algorithms yielded similar t½ independent of the type of FVIII assay used. However, there were significant differences in the time to reach 1%, 3% and 5%. The WAPPS-Hemo generated 10–12 h longer time to a trough of 1% and up to 4 h for the troughs of 3% and 5%. Accordingly, the doses estimated by WAPPS-Hemo for a daily regimen were between 28% and 100% of those proposed by MyPKFiT. Conclusions: MyPKFiT and WAPPS-Hemo provided similar half-life estimations for Octocog alfa independent of the FVIII assay used. The doses suggested by WAPPS-Hemo to reach specific troughs were overall lower, which may have implications for treatment optimization.
- Subjects :
- Adult
medicine.medical_specialty
Population
030204 cardiovascular system & hematology
Haemophilia
Hemophilia A
Hemostatics
03 medical and health sciences
Young Adult
0302 clinical medicine
Pharmacokinetics
hemic and lymphatic diseases
Internal medicine
Medicine
Humans
Dosing
education
Genetics (clinical)
Aged
education.field_of_study
Hematology
Factor VIII
business.industry
General Medicine
Middle Aged
medicine.disease
Regimen
Octocog alfa
Severe haemophilia A
business
030215 immunology
Half-Life
Subjects
Details
- ISSN :
- 13652516
- Volume :
- 27
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES
- Accession number :
- edsair.doi.dedup.....2534a0bd612f3d7c55ebdc86af768959