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Elevated circulating levels of CTRP1, a novel adipokine, in diabetic patients
- Source :
- Endocrine journal. 61(9)
- Publication Year :
- 2014
-
Abstract
- Complement C1q tumor necrosis factor-related protein 1 (CTRP1), an adipose tissue-derived adipokine has been shown to decrease blood glucose levels and to improve metabolism of glucose in mice. In addition, CTRP1 has exhibited significant association with BMI, adiponectin and TNF-α in diabetic animal models. However, there are no published studies addressing CTRP1 levels in type 2 diabetic patients. Therefore, it was of interest to evaluate plasma CTRP1 levels and associated clinical parameters and biomarkers in patients with type 2 diabetes. 135 subjects were recruited to this study, including 62 type 2 diabetic patients (DM group) and 73 healthy subjects (control group). We measured biochemical parameters, CTRP1, TNF-α and adiponectin using enzyme-linked immunosorbent assay (ELISA). Plasma CTRP1 levels showed a significant difference between the DM group and the control group (646.3 ± 154.4 ng/mL vs. 442.6 ± 165.4 ng/mL, p < 0.01). In addition, CTRP1 was strongly positively associated with BMI, glucose levels, HbA1c, HOMA-IR and TNF-α in diabetic patients. CTRP1 showed negative correlation with adiponectin. In Multivariate regression analysis, CTRP1 was strongly independently associated with diabetes when CTRP1 levels were analyzed by both as a continuous variable and quartile (OR: 1.009, 95% CI: 1.004-1.015, p < 0.05; OR: 2.443, 95% CI: 1.379-4.182, p < 0.01, respectively). Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Adipokine
Adipose tissue
Type 2 diabetes
Models, Biological
Body Mass Index
Endocrinology
Insulin resistance
Adipokines
Internal medicine
Diabetes mellitus
medicine
Homeostasis
Humans
Aged
Glycated Hemoglobin
Adiponectin
business.industry
Tumor Necrosis Factor-alpha
Type 2 Diabetes Mellitus
Proteins
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
Female
Insulin Resistance
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 13484540
- Volume :
- 61
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Endocrine journal
- Accession number :
- edsair.doi.dedup.....2586bb45aba742eb63583bc9e7e20943