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Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans
- Source :
- Donkin, I, Versteyhe, S, Ingerslev, LR, Qian, K, Mechta, M, Nordkap, L, Mortensen, B, Appel, EVR, Jørgensen, N, Kristiansen, VB, Hansen, T, Workman, C, Zierath, JR & Barrès, R 2016, ' Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans ', Cell Metabolism, vol. 23, no. 2, pp. 369–378 . https://doi.org/10.1016/j.cmet.2015.11.004
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.
- Subjects :
- Adult
Central Nervous System
Male
0301 basic medicine
medicine.medical_specialty
Physiology
Bariatric Surgery
Epigenesis, Genetic
Histones
Young Adult
03 medical and health sciences
SDG 3 - Good Health and Well-being
Thinness
Weight loss
Internal medicine
Weight Loss
medicine
Humans
Obesity
Epigenetics
Molecular Biology
Epigenesis
Regulation of gene expression
biology
Cell Biology
Epigenome
DNA Methylation
medicine.disease
030104 developmental biology
Endocrinology
Histone
Gene Expression Regulation
DNA methylation
biology.protein
RNA, Small Untranslated
CpG Islands
medicine.symptom
Subjects
Details
- ISSN :
- 15504131
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism
- Accession number :
- edsair.doi.dedup.....25ab23018a1f001291cbac928adc37e8