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Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis
- Source :
- Biomedicine & Pharmacotherapy. 103:1727-1732
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Increasing evidence showed that long non-coding RNAs (lncRNAs) play critical roles in tumor progression. FEZF1-AS1 is a cancer-associated lncRNA which upregulated and associated with poor prognosis in patients with cancer. However, the roles of FEZF1-AS1 in multiple myeloma (MM) remains unclear. In the present study, our data revealed that FEZF1-AS1 expression was increased both in MM samples and cell lines. Loss of functional assays indicated that FEZF1-AS1 suppression inhibited MM cells proliferation, arrested cell cycle in G0/G1 phase and induced cell apoptosis in vitro. Furthermore, our data indicated that FEZF1-AS1 functioned as a competing endogenous RNA in MM cells that regulated miR-610 expression, which suppressed Akt3. Those data showed that FEZF1-AS1 promoted MM cells proliferation through regulating miR-610/Akt3 axis, suggesting FEZF1-AS1 could be served as a potential target for cancer therapeutics in MM.
- Subjects :
- 0301 basic medicine
Models, Biological
03 medical and health sciences
Downregulation and upregulation
Cell Line, Tumor
Humans
Cell Proliferation
Pharmacology
Base Sequence
Chemistry
Competing endogenous RNA
Cell growth
General Medicine
Cell cycle
Long non-coding RNA
Up-Regulation
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
Tumor progression
Cell culture
Apoptosis
Gene Knockdown Techniques
Cancer research
RNA, Long Noncoding
Multiple Myeloma
Proto-Oncogene Proteins c-akt
Signal Transduction
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....25bf1c95c82e7606c13672fce82ad055