Back to Search
Start Over
Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection
- Source :
- Clinical Microbiology and Infection, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2011, 17 (10), pp.1451-1461. ⟨10.1111/j.1469-0691.2011.03640.x⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; This review gives an update of current knowledge on the clinical pleiomorphism of Leishmania, with a special emphasis on the case of asymptomatic carriage. The first part describes the numerous unusual expressions of the disease that occur besides the classic (visceral, cutaneous, and mucocutaneous) forms of leishmaniases. The second part deals with progress in the understanding of disease outcome in humans, and the possible future approaches to improve our knowledge in the field. The third part highlights the role of the too often neglected asymptomatic carrier compartment. This group could be key to understanding infraspecific differences in virulence and pathogenicity of the parasite, as well as identifying the genetic determinants involved in the expression of the disease.
- Subjects :
- Skin Leishmaniasis
MESH: Leishmaniasis
MESH: Geography
Disease outcome
clinical diversity
Disease
Review
Pathogenesis
Disease Vectors
MESH: Virulence
immune response
MESH: Dogs
0302 clinical medicine
Asymptomatic Infection
MESH: Animals
MESH: Immune Evasion
Asymptomatic Infections
Leishmaniasis
Visceral Leishmaniasis
Mammals
Leishmania
0303 health sciences
Immunity, Cellular
Geography
Virulence
Coinfection
General Medicine
parasite genetic diversity
MESH: Gene Expression Regulation
3. Good health
host susceptibility
unusual clinical forms
Infectious Diseases
Host-Pathogen Interactions
medicine.symptom
Microbiology (medical)
MESH: Leishmania
030231 tropical medicine
Mucocutaneous zone
MESH: Asymptomatic Infections
Species Difference
Biology
MESH: Disease Vectors
Asymptomatic
MESH: Mammals
MESH: Immunity, Cellular
Disease Course
03 medical and health sciences
Asymptomatic carriage
Dogs
Disease Transmission
Species Specificity
MESH: Psychodidae
medicine
Pathogenicity
Animals
Humans
MESH: Species Specificity
purl.org/pe-repo/ocde/ford#1.06.01 [https]
030304 developmental biology
Disease Reservoirs
Immune Evasion
Pleiotropy
MESH: Disease Reservoirs
MESH: Humans
Parasite Virulence
MESH: Host-Pathogen Interactions
MESH: Coinfection
Gene Expression Regulation
Immunology
Genetic Polymorphism
Psychodidae
Asymptomatic carrier
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1198743X and 14690691
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2011, 17 (10), pp.1451-1461. ⟨10.1111/j.1469-0691.2011.03640.x⟩
- Accession number :
- edsair.doi.dedup.....25ca60bc4e0f8d3f9a4ca2de79403088