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Magnesium represses trichothecene biosynthesis and modulates Tri5, Tri6, and Tri12 genes expression in Fusarium graminearum
- Source :
- Mycopathologia, Mycopathologia, Springer Verlag, 2008, 165 (1), pp.51-59. ⟨10.1007/s11046-007-9076-x⟩
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- International audience; Growth and production of type-B trichothecenes mycotoxins by the Fusarium graminearum strain CBS 185.32 were compared in GYEP medium supplemented with Mg2+ at different concentrations (0–4 mM). Mg2+ led to a strong decrease in toxin accumulation without affecting the mycelial growth, suggesting a specific Mg2+ effect on fungal secondary metabolism. Expression of Tri5, Tri6, and Tri12 genes was followed throughout the time courses of type-B trichothecenes (TCTB) yield in standard and 2 mM Mg2+-supplemented GYEP media. Mg2+ addition significantly decreased Tri5, Tri6, and Tri12 expression. The inhibition of toxin production by Mg2+ was shown to be highly correlated with inhibition of Tri5 transcription and, to a lesser extend, of Tri6 and Tri12. This is the first report of a transcriptional control of TCTB production by Mg2+.
- Subjects :
- inorganic chemicals
Fusarium
FUSARIUM GRAMINEARUM
[SDV]Life Sciences [q-bio]
Veterinary (miscellaneous)
Trichothecene
medicine.disease_cause
Applied Microbiology and Biotechnology
Microbiology
Fungal Proteins
03 medical and health sciences
chemistry.chemical_compound
Biosynthesis
Transcription (biology)
Gene Expression Regulation, Fungal
[SDV.IDA]Life Sciences [q-bio]/Food engineering
Transcriptional regulation
medicine
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
Magnesium
Secondary metabolism
Gene
030304 developmental biology
0303 health sciences
biology
Reverse Transcriptase Polymerase Chain Reaction
030306 microbiology
Toxin
RNA, Fungal
biology.organism_classification
chemistry
TRANSCRIPTIONAL CONTROL
Trichothecenes
Agronomy and Crop Science
Subjects
Details
- ISSN :
- 15730832 and 0301486X
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Mycopathologia
- Accession number :
- edsair.doi.dedup.....25e4fb194fae41739f371d785d68402f