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Microarray findings in pregnancies with oligohydramnios - a retrospective cohort study and literature review
- Source :
- Journal of perinatal medicineReferences. 48(1)
- Publication Year :
- 2019
-
Abstract
- Objective To explore the risk for abnormal chromosomal microarray analysis (CMA) findings in pregnancies with oligohydramnios. Methods Data from all CMA analyses performed due to oligohydramnios between 2013 and 2017 were retrospectively obtained from the Israeli Ministry of Health database. The rate of clinically significant (pathogenic and likely pathogenic) findings was compared to a local cohort of pregnancies with normal ultrasound, yielding a 1.4% rate of abnormal CMA results. In addition, a search was conducted through the PubMed database addressing the issue. Results Fifty CMA analyses were performed due to oligohydramnios. The 2% risk for clinically significant CMA finding in pregnancies with oligohydramnios did not differ from the control population of 5541 pregnancies with normal ultrasound – relative risk (RR) 1.4 [95% confidence interval (CI) 0.2–10.2]. Literature search yielded 394 titles, of which four relevant articles were selected, all using fetal karyotyping. Conclusion There is yet insufficient evidence to support invasive prenatal testing in pregnancies with isolated oligohydramnios.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Microarray
DNA Copy Number Variations
Oligohydramnios
03 medical and health sciences
Young Adult
0302 clinical medicine
Pregnancy
Medicine
Humans
Likely pathogenic
Retrospective Studies
Chromosome Aberrations
business.industry
Obstetrics
Obstetrics and Gynecology
Retrospective cohort study
medicine.disease
Microarray Analysis
Confidence interval
030104 developmental biology
Relative risk
Pediatrics, Perinatology and Child Health
Cohort
Christian ministry
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16193997
- Volume :
- 48
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of perinatal medicineReferences
- Accession number :
- edsair.doi.dedup.....25ee414b6c39dd511ba5d42725c942f0