Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus

Authors :: Wanju Zhang
Di Tian
Chao Qiu
Zhenghong Yuan
Anli Zhang
Yanmin Wan
Zhiyong Zhang
Yang Huang
Jianqing Xu
Xiaoling Zhang
Xiaoyan Zhang
Yunwen Hu
Source :: Emerging Infectious Diseases, Vol 19, Iss 10, Pp 1685-1687 (2013), Emerging Infectious Diseases
Publication Year :: 2013
Publisher :: Centers for Disease Control and Prevention, 2013.
Abstract: Serologic studies are urgently needed to assist in understanding an outbreak of influenza A(H7N9) virus. However, a biosafety level 3 laboratory is required for conventional serologic assays with live lethal virus. We describe a safe pseudovirus-based neutralization assay with preliminary assessment using subtype H7N9-infected samples and controls.

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