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Serum lipoprotein(a) and risk of mortality in patients on peritoneal dialysis
- Source :
- Journal of clinical lipidology. 14(2)
- Publication Year :
- 2019
-
Abstract
- Background Elevated serum lipoprotein(a) [Lp(a)] level is an independent risk factor for atherosclerotic diseases in the general population and hemodialysis patients. However, the association between Lp(a) levels and mortality has received little attention in peritoneal dialysis (PD) patients. Objective The objective of the study was to evaluate the association of Lp(a) levels with all-cause and cardiovascular (CV) mortality in PD patients. Methods This retrospective cohort study was conducted in PD patients enrolled from January 1, 2006 to December 31, 2015, and followed until December 31, 2018. Cox regression models were performed to assess the association of serum Lp(a) levels with all-cause and CV mortality in PD patients. Results In total, 1492 incident PD patients were eligible for the study. During a median follow-up period of 45.1 months, 402 all-cause and 210 CV deaths occurred. Multivariate Cox regression analysis revealed that the first and third tertiles of Lp(a) levels were significantly associated with increased risk for all-cause mortality [hazard ratio (HR) = 1.33, 95% confidence interval (95% CI) = 1.01–1.75, P = .041; HR = 1.53, 95% CI = 1.18–1.98, P = .001, respectively] when compared with the second tertile, and the third tertile of Lp(a) level was independently associated with an 80% increased risk of CV mortality (HR = 1.80, 95% CI = 1.26–2.56, P = .001). Moreover, our results showed that the HRs per log unit higher Lp(a) level for all-cause and CV mortality were 1.53 (95% CI = 1.05–2.22, P = .027) and 2.41 (95% CI = 1.44–4.03, P Conclusions Our results suggest that both low and high serum Lp(a) levels are risk markers for all-cause death, but only a higher baseline serum Lp(a) level is an independent risk factor for CV mortality in PD patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Population
030204 cardiovascular system & hematology
Gastroenterology
Peritoneal dialysis
Cohort Studies
03 medical and health sciences
Young Adult
0302 clinical medicine
Risk Factors
Internal medicine
Internal Medicine
medicine
Risk of mortality
Humans
030212 general & internal medicine
Risk factor
education
Aged
Retrospective Studies
education.field_of_study
Nutrition and Dietetics
biology
business.industry
Hazard ratio
Retrospective cohort study
Lipoprotein(a)
Middle Aged
Cardiovascular Diseases
biology.protein
Female
Cardiology and Cardiovascular Medicine
business
Peritoneal Dialysis
Cohort study
Follow-Up Studies
Subjects
Details
- ISSN :
- 19332874
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of clinical lipidology
- Accession number :
- edsair.doi.dedup.....262c544247ad761c183c9a7f19601ae2