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Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 1100, p 1100 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Atherosclerosis remains a large health and economic burden. Even though it has been studied for more than a century, its complex pathophysiology has not been elucidated. The relatively well-established contributors include: chronic inflammation in response to oxidized cholesterol, reactive oxygen species-induced damage and apoptosis. Recently, profilin 1, a regulator of actin dynamics emerged as a potential new player in the field. Profilin is abundant in stable atherosclerotic plaques and in thrombi extracted from infarct-related arteries in patients with acute myocardial infarction. The exact role of profilin in atherosclerosis and its complications, as well as its mechanisms of action, remain unknown. Here, we summarize several pathways in which profilin may act through mitochondria in a number of processes implicated in atherosclerosis.
- Subjects :
- 0301 basic medicine
Myocardial Infarction
Apoptosis
Review
030204 cardiovascular system & hematology
Mitochondrion
Coronary artery disease
Pathogenesis
lcsh:Chemistry
Mice
Profilins
0302 clinical medicine
Sirtuin 3
Protein Isoforms
Myocardial infarction
lcsh:QH301-705.5
Spectroscopy
biology
General Medicine
Pathophysiology
Plaque, Atherosclerotic
Computer Science Applications
mitochondria
Profilin
Reperfusion Injury
Acute Disease
medicine.symptom
coronary artery disease
profilin 1
Inflammation
macromolecular substances
Catalysis
Inorganic Chemistry
03 medical and health sciences
Profilin-1
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
business.industry
Organic Chemistry
medicine.disease
Atherosclerosis
Actins
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Immunology
biology.protein
business
Reactive Oxygen Species
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 1100
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....2631ceda6739057f309880a92cc07d36