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Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?

Authors :
Wojciech Zajdel
Elżbieta Paszek
Krzysztof Żmudka
Tomasz Rajs
Jacek Legutko
Paweł Kleczyński
Source :
International Journal of Molecular Sciences, Vol 22, Iss 1100, p 1100 (2021), International Journal of Molecular Sciences
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Atherosclerosis remains a large health and economic burden. Even though it has been studied for more than a century, its complex pathophysiology has not been elucidated. The relatively well-established contributors include: chronic inflammation in response to oxidized cholesterol, reactive oxygen species-induced damage and apoptosis. Recently, profilin 1, a regulator of actin dynamics emerged as a potential new player in the field. Profilin is abundant in stable atherosclerotic plaques and in thrombi extracted from infarct-related arteries in patients with acute myocardial infarction. The exact role of profilin in atherosclerosis and its complications, as well as its mechanisms of action, remain unknown. Here, we summarize several pathways in which profilin may act through mitochondria in a number of processes implicated in atherosclerosis.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
22
Issue :
1100
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....2631ceda6739057f309880a92cc07d36