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Prevalence of the apolipoprotein E E4 allele in amyloid B positive subjects across the spectrum of Alzheimer's disease
- Source :
- Alzheimer's & Dementia, 14(7), 913-924. Elsevier Science, Alzheimer's & Dementia, 14, 7, pp. 913-924, Alzheimer's & Dementia, Alzheimers & Dementia, Alzheimer's & Dementia, Vol. 14, No 7 (2018) pp. 913-924, Alzheimer's and dementia 14(7), 913-924 (2018). doi:10.1016/j.jalz.2018.02.009, Alzheimer's & Dementia, 14, 913-924, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Alzheimer's and Dementia, 14(7), 913-924, Alzheimer's and Dementia, 14(7), 913-924. Elsevier, Alzheimer's & dementia, Mattsson, N, Groot, C, Jansen, W J, Landau, S M, Villemagne, V L, Engelborghs, S, Mintun, M M, Lleo, A, Molinuevo, J L, Jagust, W J, Frisoni, G B, Ivanoiu, A, Chételat, G, Resende de Oliveira, C, Rodrigue, K M, Kornhuber, J, Wallin, A, Klimkowicz-Mrowiec, A, Kandimalla, R, Popp, J, Aalten, P P, Aarsland, D, Alcolea, D, Almdahl, I S, Baldeiras, I, van Buchem, M A, Cavedo, E, Chen, K, Cohen, A D, Förster, S, Fortea, J, Frederiksen, K S, Freund-Levi, Y, Gill, K D, Gkatzima, O, Grimmer, T, Hampel, H, Herukka, S K, Johannsen, P, van Laere, K, de Leon, M J, Maier, W, Marcusson, J, Meulenbroek, O, Møllergård, H M, Morris, J C, Mroczko, B, Nordlund, A, Prabhakar, S, Peters, O, Rami, L, Rodríguez-Rodríguez, E, Roe, C M, Rüther, E, Santana, I, Schröder, J, Seo, S W, Soininen, H, Spiru, L, Stomrud, E, Struyfs, H, Teunissen, C E, Verhey, F R J, Vos, S J B, van Waalwijk van Doorn, L J C, Waldemar, G, Wallin, Å K, Wiltfang, J, Vandenberghe, R, Brooks, D J, Fladby, T, Rowe, C C, Drzezga, A, Verbeek, M M, Sarazin, M, Wolk, D A, Fleisher, A S, Klunk, W E, Na, D L, Sánchez-Juan, P, Lee, D Y, Nordberg, A, Tsolaki, M, Camus, V, Rinne, J O, Fagan, A M, Zetterberg, H, Blennow, K, Rabinovici, G D, Hansson, O, van Berckel, B N M, van der Flier, W M, Scheltens, P, Visser, P J & Ossenkoppele, R 2018, ' Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease ', Alzheimer's and Dementia, vol. 14, no. 7, pp. 913-924 . https://doi.org/10.1016/j.jalz.2018.02.009
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P
- Subjects :
- 0301 basic medicine
Apolipoprotein E
Male
NATIONAL INSTITUTE
Neurology
Epidemiology
Apolipoprotein E4
LONGITUDINAL COHORT
Disease
metabolism [Cognitive Dysfunction]
ddc:616.89
0302 clinical medicine
Prevalence
Geographical location
genetics [Apolipoprotein E4]
APOE GENOTYPE
Health Policy
GLUCOSE-METABOLISM
CEREBROSPINAL-FLUID BIOMARKERS
Alzheimer's disease
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
3. Good health
Europe
Psychiatry and Mental health
cerebrospinal fluid [Biomarkers]
Biomarker (medicine)
lipids (amino acids, peptides, and proteins)
Female
Sex
ASSOCIATION WORKGROUPS
metabolism [Alzheimer Disease]
APOE
medicine.medical_specialty
Amyloid
CSF BIOMARKERS
metabolism [Amyloid beta-Peptides]
CSF
ta3112
Education
03 medical and health sciences
Cellular and Molecular Neuroscience
Age
Developmental Neuroscience
Alzheimer Disease
Internal medicine
mental disorders
medicine
Dementia
Humans
Cognitive Dysfunction
ddc:610
Allele
OLDER-ADULTS
Biology
Alleles
Aged
Amyloid beta-Peptides
business.industry
Mild cognitive impairment
medicine.disease
nervous system diseases
030104 developmental biology
Endocrinology
PET
Positron-Emission Tomography
ddc:618.97
Subjective cognitive decline
DIAGNOSTIC GUIDELINES
Human medicine
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 15525260
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia, 14(7), 913-924. Elsevier Science, Alzheimer's & Dementia, 14, 7, pp. 913-924, Alzheimer's & Dementia, Alzheimers & Dementia, Alzheimer's & Dementia, Vol. 14, No 7 (2018) pp. 913-924, Alzheimer's and dementia 14(7), 913-924 (2018). doi:10.1016/j.jalz.2018.02.009, Alzheimer's & Dementia, 14, 913-924, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Alzheimer's and Dementia, 14(7), 913-924, Alzheimer's and Dementia, 14(7), 913-924. Elsevier, Alzheimer's & dementia, Mattsson, N, Groot, C, Jansen, W J, Landau, S M, Villemagne, V L, Engelborghs, S, Mintun, M M, Lleo, A, Molinuevo, J L, Jagust, W J, Frisoni, G B, Ivanoiu, A, Chételat, G, Resende de Oliveira, C, Rodrigue, K M, Kornhuber, J, Wallin, A, Klimkowicz-Mrowiec, A, Kandimalla, R, Popp, J, Aalten, P P, Aarsland, D, Alcolea, D, Almdahl, I S, Baldeiras, I, van Buchem, M A, Cavedo, E, Chen, K, Cohen, A D, Förster, S, Fortea, J, Frederiksen, K S, Freund-Levi, Y, Gill, K D, Gkatzima, O, Grimmer, T, Hampel, H, Herukka, S K, Johannsen, P, van Laere, K, de Leon, M J, Maier, W, Marcusson, J, Meulenbroek, O, Møllergård, H M, Morris, J C, Mroczko, B, Nordlund, A, Prabhakar, S, Peters, O, Rami, L, Rodríguez-Rodríguez, E, Roe, C M, Rüther, E, Santana, I, Schröder, J, Seo, S W, Soininen, H, Spiru, L, Stomrud, E, Struyfs, H, Teunissen, C E, Verhey, F R J, Vos, S J B, van Waalwijk van Doorn, L J C, Waldemar, G, Wallin, Å K, Wiltfang, J, Vandenberghe, R, Brooks, D J, Fladby, T, Rowe, C C, Drzezga, A, Verbeek, M M, Sarazin, M, Wolk, D A, Fleisher, A S, Klunk, W E, Na, D L, Sánchez-Juan, P, Lee, D Y, Nordberg, A, Tsolaki, M, Camus, V, Rinne, J O, Fagan, A M, Zetterberg, H, Blennow, K, Rabinovici, G D, Hansson, O, van Berckel, B N M, van der Flier, W M, Scheltens, P, Visser, P J & Ossenkoppele, R 2018, ' Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease ', Alzheimer's and Dementia, vol. 14, no. 7, pp. 913-924 . https://doi.org/10.1016/j.jalz.2018.02.009
- Accession number :
- edsair.doi.dedup.....26354f2b3bd8d24cb332c416834e0b88
- Full Text :
- https://doi.org/10.1016/j.jalz.2018.02.009