Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy

Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo popula- tion. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy (P