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Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options
- Source :
- AIDS Res Hum Retroviruses
- Publication Year :
- 2020
- Publisher :
- Mary Ann Liebert Inc, 2020.
-
Abstract
- A growing body of research is beginning to elucidate reasons people living with HIV (PLWHIV) might prefer oral daily antiretroviral treatment (ART) compared with emerging long-acting ART (LA-ART) or HIV remission strategies under investigation. Our objective is to provide qualitative insights into the reasons why PLWHIV might prefer one of these HIV control therapies over others. From May to August 2018, we implemented a semistructured cross-sectional survey of PLWHIV in the United States to better understand patient preferences around various HIV treatment and remission options. Using free text, respondents were asked to explain why they preferred one HIV control option over the other two. We analyzed responses to the open-ended survey questions on reasons for preferring oral daily ART versus LA-ART versus HIV remission strategies using conventional content analysis. The results showed that PLWHIV preferred oral daily ART because of its familiarity and known safety and efficacy profile, whereas those who preferred LA-ART would value the convenience it offers. Finally, HIV remission strategies would be preferred to avoid taking ART altogether. The qualitative results provide insights into reasons why PLWHIV in the United States might prefer oral daily ART versus novel therapies. More importantly, they provide information to better align HIV virological control strategies with end-user perspectives. To make informed choices around evolving HIV therapeutics, PLWHIV and HIV care providers would benefit from decision tools to better assess options and trade-offs. More research is needed on how best to effectively support PLWHIV and HIV care providers in shared decision-making.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Surveys and Questionnaires
Virology
Control option
Antiretroviral treatment
medicine
Text messaging
Humans
030212 general & internal medicine
Hiv treatment
business.industry
Patient preference
Antiretroviral therapy
Research Personnel
Cross-Sectional Studies
030104 developmental biology
Infectious Diseases
Long acting
Anti-Retroviral Agents
Family medicine
Sociobehavioral
business
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....265a683acf700d029d6b612ea2d5beb1