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Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: in vitro studies
- Source :
- Metabolism. 53:563-570
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Sex steroids play an important role in modulating pulsatile growth hormone (GH) release, acting at both hypothalamic and pituitary level in both humans and experimental animals. Selective estrogen receptor modulators (SERMs) act as either estrogen receptor agonists or antagonists in a tissue-selective manner. In postmenopausal women, serum GH levels correlate positively with endogenous estradiol levels and insulin-like grwoth factor-I (IGF-I) is positively related to bone mineral density (BMD) at the spine and hip. The aim of the present study was to evaluate, for the first time, the direct effect of LY117018, an analog of raloxifene, on GH secretion from both human and rodent pituitary cells in vitro. Our results demonstrated that pharmacological concentrations of the raloxifene analog LY117018 can stimulate GH secretion through a direct action on the pituitary. LY117018 also showed an estrogen-like activity, inducing the proliferation of rat pituitary GH-secreting adenomatous cells (GH1).
- Subjects :
- Adenoma
Adult
Male
Selective Estrogen Receptor Modulators
medicine.medical_specialty
Pyrrolidines
medicine.drug_class
Endocrinology, Diabetes and Metabolism
LY117018
pituitary adenoma
Endogeny
Thiophenes
Growth Hormone-Releasing Hormone
Rats, Sprague-Dawley
Endocrinology
Internal medicine
medicine
Animals
Humans
Raloxifene
Secretion
Cells, Cultured
Estrogen receptor beta
Aged
pituitary adenomas
growth hormone
tamoxifen
Dose-Response Relationship, Drug
Estradiol
Chemistry
Middle Aged
In vitro
Growth hormone secretion
Rats
Tamoxifen
Selective estrogen receptor modulator
Estrogen
Growth Hormone
Pituitary Gland
Raloxifene Hydrochloride
Female
Secretory Rate
Cell Division
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00260495
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Metabolism
- Accession number :
- edsair.doi.dedup.....2669e34c0742ea8ededac1cf402ddadb