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Eruption of lymphocyte recovery with atypical lymphocytes mimicking a primary cutaneous T-cell lymphoma: a series of 12 patients
- Source :
- Human pathology. 71
- Publication Year :
- 2017
-
Abstract
- Eruption of lymphocyte recovery (ELR) may occur during bone marrow aplasia after chemotherapies. We reviewed the clinical and pathologic features of 12 patients (male-female ratio, 7:5; median age, 61 years) with an atypical ELR histologically mimicking a primary cutaneous T-cell lymphoma such as Sezary syndrome or CD30+ T-cell lymphoproliferative disorder. All the patients displayed an erythematous maculopapular eruption on the trunk and the limbs associated with fever. All but one had received a polychemotherapy for an acute myeloid leukemia (n=10) or a urothelial carcinoma (n=1) before the occurrence of the skin eruption. One had an autoimmune lymphoproliferative syndrome causing chronic agranulocytosis requiring granulocyte colony-stimulating factor injection. In all patients, the skin eruption was associated with a slight increase of white blood cell count followed by bone marrow recovery within the next weeks. All skin biopsies showed a dermal perivascular lymphocytic infiltrate containing atypical medium- to large-sized CD3+, CD4+ and CD8+, CD25+, ICOS+, PD1- lymphocytes with a strong CD30 expression in most instances (n=10), suggesting the recruitment of strongly activated T cells in the skin. In 6 patients, a diagnosis of CD30+ lymphoproliferative disorder or Sezary syndrome was proposed or suspected histopathologically, and only the clinical context allowed the diagnosis of ELR with a peculiar presentation with atypical lymphocytes. We describe a series of patients with an unusual form of ELR characterized by the presence of atypical activated T cells in the skin. On a practical ground, pathologists should be aware of this distinctive and misleading presentation.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Skin Neoplasms
Lymphocyte
T-Lymphocytes
Lymphocyte Activation
Pathology and Forensic Medicine
Diagnosis, Differential
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
White blood cell
Antineoplastic Combined Chemotherapy Protocols
medicine
Pseudolymphoma
Maculopapular rash
Humans
610 Medicine & health
Aged
Aged, 80 and over
Atypical Lymphocyte
integumentary system
business.industry
Cutaneous T-cell lymphoma
Middle Aged
medicine.disease
Lymphoma, T-Cell, Cutaneous
medicine.anatomical_structure
030220 oncology & carcinogenesis
Autoimmune lymphoproliferative syndrome
Female
Bone marrow
Drug Eruptions
medicine.symptom
business
Subjects
Details
- ISSN :
- 15328392
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Human pathology
- Accession number :
- edsair.doi.dedup.....266a8c7fbf3ada692b98a2d4e41fc5c6